Invega Sustenna^®

• Schizophrenia in adults⁴

Initiation Regimen Required for Schizophrenia

Yes⁴

Oral Supplementation Required During Initiation for Schizophrenia

No⁴

Initiation Regimen for Schizophrenia*

150 mg on Day 1
100 mg on Day 8

*If the patient had never taken oral paliperidone or oral or injectable risperidone, it is recommended to establish tolerability with oral paliperidone or oral risperidone prior to initiating treatment with INVEGA SUSTENNA.

Disease States

• Schizophrenia in adults⁴

Reconstitution Required

No⁴

How Supplied

Prefilled syringe

Preparation Instructions

Shake the syringe containing INVEGA SUSTENNA for a minimum of 10 seconds to ensure a homogenous suspension.⁴

Requirements Once Prepared or Reconstituted

None stated in the PI

Number of Dosing Options Available

5⁴

Preparation Kits Available

Single-dose, prefilled syringe kit

• 39 mg
• 78 mg
• 117 mg
• 156 mg
• 234 mg⁴

Dose Strengths

• 39 mg (equivalent to 25 mg paliperidone)
• 78 mg (equivalent to 50 mg paliperidone)
• 117 mg (equivalent to 75 mg paliperidone)
• 156 mg (equivalent to 100 mg paliperidone)
• 234 mg (equivalent to 150 mg paliperidone)⁴

Equivalencies

None stated in PI

Maintenance Dose for Schizophrenia

75 mg
(some patients may benefit from lower or higher doses within the recommended range of 25 - 150 mg)

• Q1M⁴

0.25 mL (39 mg dose) - 1.5 mL (234 mg dose):⁴

• 0.25 mL (39 mg dose)
• 0.5 mL (78 mg dose)
• 0.75 mL (117 mg dose)
• 1.0 mL (156 mg dose)
• 1.5 mL (234 mg dose)⁴

Needle Lengths

1, 1.5⁴

Needle Gauges

22, 23⁴

Injection Site(s)

IM (deltoid or gluteal)⁴

Deltoid Administration (Needle Gauge & Length)

For patients weighing less than 90 kg, the 1-inch, 23 gauge needle is recommended
For patients weighing 90 kg or more, the 1.5-inch, 22 gauge needle is recommended⁴

Gluteal Administration (Needle Gauge & Length)

The recommended needle size for administration into the gluteal muscle is the 1.5-inch, 22 gauge needle regardless of patient weight⁴

Subcutaneous Administration (Needle Gauge & Length)

n/a

How Supplied

Prefilled syringe

Preparation Kits Available

Single-dose, prefilled syringe kit

• 39 mg
• 78 mg
• 117 mg
• 156 mg
• 234 mg⁴

Kit Contents

1 single-dose, prefilled syringe containing INVEGA SUSTENNA aqueous suspension with backstop, a plunger stopper, and tip cap
+
2 safety needles to choose from for drug administration⁴

Kit Storage (Refrigeration Required)

No⁴

Kit Storage (Specific Temperature Requirements)

Store below 25°C

Kit Storage (Excursions Permitted)

None stated in PI

Kit Storage (Protect from Light)

Not stated in PI

Kit Storage (Other Requirements)

Not stated in PI

Temperature Requirements for Drug Preparation

Room Temperature⁴

Preparation Instructions

Shake the syringe containing INVEGA SUSTENNA for a minimum of 10 seconds to ensure a homogenous suspension.⁴

Requirements Once Prepared or Reconstituted

None stated in the PI